Functional Assay
Rdcthera offers all functional assay services in flow cytometry during radiopharmaceutical research. We are a preclinical Contract Research Organization dedicated to delivering premier quality services that foster the development of newer treatments. In this regard, we can utilize deep knowledge of flow cytometry to execute cellular analysis with very high accuracy. Such cellular analysis forms a core component of understanding pharmacodynamics and efficacy for radiopharmaceuticals.
Flow Cytometry-Based Functional Assays
Flow cytometry is a technique that allows for the measurement of physical and chemical characteristics of cells or particles. This technique allows for the simultaneous multiple-parameter analysis of physical and chemical properties of up to thousands of particles per second. In radiopharmaceuticals, flow cytometry-based functional assays define cellular responses and functions, including proliferation, signal transduction, and immune cell activity.
Fig.1. Measurable neutrophil functions by flow cytometry. (Timmer KD, et al., 2023)
Our Comprehensive Functional Assay Services
We have a multitude of functional assays tailored for specific applications in radiopharmaceutical research.
| Assay Type |
Description |
| Cellular Proliferation |
Estimate cell growth and division in order to describe radiopharmaceutical influence on cellular replication, a key point in assessing therapeutic potential or cytotoxicity. |
| Endocytosis and Exocytosis |
Explore the intracellular delivery and release mechanisms of radiopharmaceuticals, aiding in the development of efficient drug delivery systems. |
| Calcium Signaling |
Study radiopharmaceutical effects on calcium dynamics and reveal new potential therapeutic mechanisms. |
| Oxidative Metabolism |
It measures metabolic activity and ROS production to determine the efficacy of radiopharmaceuticals and involved oxidative effects. |
| NK Cell Function |
Assess the impact of radiopharmaceuticals on NK cell activity, supporting the development of effective immunotherapeutic strategies. |
| Basophil Activation |
Examine the effects on basophil activity to understand potential allergic reactions and immunomodulatory effects of radiopharmaceuticals. |
Why Work With Rdcthera?
- Proven Expertise - Since the members of the team are one of the leading scientists involved in radiopharmaceutical research and flow cytometry, the highest level of expertise is guaranteed.
- Tailored Solutions - We provide tailored assay services that are crafted for clear, defined research goals in whatever particular area to ensure high precision and flexibility.
- Cutting Edge of Technology - We have state-of-the-art laboratories with the most advanced flow cytometry instruments that facilitate comprehensive and high-throughput analyses.
- Quality Assurance - We apply strict quality control measures to ensure the accuracy and reproducibility of our results.
Ready to take the next step in your radiopharmaceutical research? Contact Rdcthera today to learn more about our flow cytometry based functional assay services and how we can support your projects.
Reference
- Timmer KD, Floyd DJ, Scherer AK, et al. (2023). Multiparametric Profiling of Neutrophil Function via a High-Throughput Flow Cytometry-Based Assay. Cells. 12(5):743.
For research use only. Not intended for any clinical use.
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