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Lipophilicity Study Services of Radioconjugates

Rdcthera is a leading contract research organization (CRO) that specialized in applied radiochemical research and development. We are committed to advancements in the field of nuclear medicine, offering a range of services including lipophilicity study services for radioconjugates.

Overview of Radioconjugate Lipophilicity Studies

Lipophilicity (lipid solubility) is the ability of a compound to dissolve in a non-polar solvent and is usually determined by the partitioning behaviour of the compound in a liquid-liquid or liquid-solid two-phase system. Lipophilicity of a radioconjugate plays a very important role in pharmacology, pharmacokinetics and toxicology, therefore, the study of lipophilicity of the tested compounds helps in establishing the drug conformational relationship. Prediction of the lipophilicity of test compounds helps in the study of the ADMET properties of compounds, which helps the researchers to find out the druggability problems at an early stage, and it can reduce the elimination rate of the drug candidates at the stage of clinical research. The amount of compound detection in the early stage of drug screening is very large, therefore, drug developers are eager to find a rapid and accurate method to determine the lipophilicity of the drug to help drug screening research.

Our Services

Lipophilicity (logD/P) is an important part of physicochemical property testing in drug discovery and development. Rdcthera offers a comprehensive range of lipophilicity testing methods, reversed-phase liquid chromatography (RP-HPLC), classical shake flask, potentiometric titration, and computer simulation, which can be adapted to different scenarios to accelerate the development of drug discovery and development.

  • RP-HPLC Method

A selected reference compound is injected into the chromatographic system, the retention time of the reference compound is obtained and its capacity factor is calculated. The logarithm of the capacity factor is used to make a linear regression equation with the known logP of the reference compound, which is called the standard equation. Based on the retention time of the compound to be tested under the same chromatographic conditions, the capacity factor is calculated and brought into the standard equation to obtain the logP of the compound to be tested.The most important part of this process is the establishment of the standard equation.

  • Shake Flask Method

The pH range of the universal buffer solution is from 3 to 11, and the logD value at each pH is detected at an interval of 1 pH, and the logD vs pH curve is plotted to deduce the logP, and the pH of the logP is within the range of pH 3 to 11 for accurate determination.

  • Potentiometric Titration Method

The compounds were titrated in the pH 2-12 range to obtain the titration curves of the compounds in aqueous solution and in the presence of n-octanol, and the lipophilicity was calculated from the displacement of the titration curves due to the partitioning of the compounds into octanol.


  • Optimizing Blood-Brain Barrier Crossing
  • Pharmacokinetic Profile Assessment
  • Targeted Delivery Enhancement
  • Mentoring the Drug Discovery Team
  • Drug Formulation Design

Ready to embark on your lipophilicity study journey? Contact us today to learn more about our services, discuss your project requirements, and explore how we can support your research and development endeavors in the exciting realm of radioconjugates. Unlock the potential of radioconjugates with Rdcthera - your trusted partner in lipophilicity study services.

For research use only. Not intended for any clinical use.

Rdcthera RDC

Rdcthera offers efficient, customized, and professional R&D services related to radionuclide drug conjugates.

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